Anti-CDC6 Antibody(monoclonal, DCS-180)

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品名：Anti-CDC6 Antibody(monoclonal, DCS-180)
品牌：博士德
货号：BM1579

货号：BM1579

应用：WB

反应性：Human

克隆性：单克隆抗体

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SKU	包装规格	单位	目录价	您的价格	库存
BM1579-100ul	100ul	EA	¥1780.00	请登录	请登录
BM1579-150ul	150ul	EA	¥2580.00	请登录	请登录
BM1579-50ul	50ul	EA	¥1060.00	请登录	请登录

产品概况

货号	BM1579
产品名称	Anti-CDC6 Antibody(monoclonal, DCS-180)
基因名	CDC6
抗体来源	Mouse
克隆	Monoclonal (Clone: DCS-180)
抗体亚型	Mouse IgG1
分子量	63KD
免疫原	Recombinant human Cdc6.
内容	200ug/ml antibody with PBS ，0.02% NaN3 , 1mg BSA and 50% glycerol.
纯化方式	Ascites
浓度	200ug/ml
产品形态	Liquid
保存条件	12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料	In yeasts, Cdc6(Saccharomyces cerevisiae) and Cdc18(Schizosaccharomyces pombe) associate with the origin recognition complex(ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al.(1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.
研究类别	1. Gonzalez, S.; Klatt, P.; Delgado, S.; Conde, E.; Lopez-Rios, F.; Sanchez-Cespedes, M.; Mendez, J.; Antequera, F.; Serrano, M. : Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440: 702-706, 2006.2. Yan, Z.; DeGregori, J.; Shohet, R.; Leone, G.; Stillman, B.; Nevins, J. R.; Williams, R. S. : Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc. Nat. Acad. Sci. 95: 3603-3608, 1998.
Uniprot ID	CDC6: Q99741
推荐配套的二抗和检测试剂	Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and ICC.