Anti-CDKN1B Antibody(monoclonal, DCS-72)

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品名：Anti-CDKN1B Antibody(monoclonal, DCS-72)
品牌：博士德
货号：BM1594

货号：BM1594

应用：WB, ICC

反应性：Human, Mouse, Rat

克隆性：单克隆抗体

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SKU	包装规格	单位	目录价	您的价格	库存
BM1594-100ul	100ul	EA	¥1780.00	请登录	请登录
BM1594-150ul	150ul	EA	¥2580.00	请登录	请登录
BM1594-50ul	50ul	EA	¥1060.00	请登录	请登录

产品概况

货号	BM1594
产品名称	Anti-CDKN1B Antibody(monoclonal, DCS-72)
基因名	CDKN1B
抗体来源	Mouse
克隆	Monoclonal (Clone: DCS-72)
抗体亚型	Mouse IgG1
分子量	27KD
免疫原	recombinant rodent p27Kip1 protein.
内容	200ug/ml antibody with PBS ，0.02% NaN3 , 1mg BSA and 50% glycerol.
纯化方式	Ascites
浓度	200 ug/ml
产品形态	Liquid
保存条件	12 months from date of receipt，-20℃ as supplied.6 months 2 to 25℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料	P27(kip1), also known as cyclin dependent kinase inhibitor 1B(CDKN1B), is a major target of AFX-like forkhead proteins. CDKN1B(p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper. Phosphorylation leads to the ubiquitination and degradation of CDKN1B. P27(kip1) mapped to 12p13. An increase in p27 causes proliferating cells to exit from the cell cycle, and a decrease in p27 is necessary for quiescent cells to resume division. Abnormally low amounts of p27 are associated with pathological states of excessive cell proliferation, especially cancers. Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells.
研究类别	1. Chang, B.; Zheng, S. L.; Isaacs, S. D.; Wiley, K. E.; Turner, A.; Li, G.; Walsh, P. C.; Meyers, D. A.; Isaacs, W. B.; Xu, J. : A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer. Cancer Res. 64: 1997-1999, 2004. 2. Malek, N. P.; Sundberg, H.; McGrew, S.; Nakayama, K.; Kyriakidis, T. R.; Roberts, J. M. : A mouse knock-in model exposes sequential proteolytic pathways that regulate p27(Kip1) in G1 and S phase. Nature 413: 323-327, 2001. 3. Mitsuhashi, T.; Aoki, Y.; Eksioglu, Y. Z.; Takahashi, T.; Bhide, P. G.; Reeves, S. A.; Caviness, V. S., Jr. : Overexpression of p27(Kip1) lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells. Proc. Nat. Acad. Sci. 98: 6435-6440, 2001.
Uniprot ID	CDKN1B: P46527
推荐配套的二抗和检测试剂	Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and ICC.