Anti-ANGPTL3 Antibody

货号:A02929
应用:WB
反应性:Human, Mouse, Rat
克隆性:多克隆抗体
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A02929-100ul 100ul EA ¥1780.00 请登录 请登录
A02929-150ul 150ul EA ¥2580.00 请登录 请登录
A02929-50ul 50ul EA ¥1060.00 请登录 请登录

产品概况

货号A02929
产品名称Anti-ANGPTL3 Antibody
基因名ANGPTL3
抗体来源Rabbit
克隆Polyclonal
抗体亚型Rabbit IgG
分子量54KD
免疫原A synthetic peptide corresponding to a sequence of human ANGPTL3 (RFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLN).
内容500 ug/ml antibody with PBS ,0.02% NaN3 , 1 mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500 ug/ml
产品形态Liquid
保存条件12 months from date of receipt,-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料ANGPTL3 (Angiopoietin-Like 3), also known as ANGPT5, is a protein which in humans is encoded by the ANGPTL3 gene. The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. By radiation hybrid mapping and the use of surrounding genes, this gene is mapped to chromosome 1p31. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels.
研究类别1. Camenisch, G, Pisabarro, M. T., Sherman, D., Kowalski, J., Nagel, M., Hass, P, Xie, M.-H., Gurney, A., Bodary, S., Liang, X. H., Clark, K., Beresini, M, Ferrara, N., Gerber, H.-P. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha-v-beta-3 and induces blood vessel formation in vivo. J. Biol. Chem. 277: 17281-17290, 2002.2. Conklin, D., Gilbertson, D., Taft, D. W., Maurer, M. F., Whitmore, T. E., Smith, D. L., Walker, K. M., Chen, L. H., Wattler, S., Nehls, M., Lewis, K. B. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 62: 477-482, 1999.3. Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., Furukawa, H. Angptl3 regulates lipid metabolism in mice. Nature Genet. 30: 151-157, 2002.
Uniprot IDANGPTL3: Q9Y5C1
推荐配套的二抗和检测试剂Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). *Blocking peptide 可以联系我们购买。

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[list_product_images]Figure 1. Western blot analysis of ANGPTL3 using anti-ANGPTL3 antibody (A02929). Lane 1: mouse HEPA1-6 cell lysate. anti-ANGPTL3 antigen affinity purified polyclonal antibody (Catalog # A02929)probed with a goat anti-rabbit IgG-HRP secondary antibody The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) . A specific band was detected for ANGPTL3 at approximately 54KD. The expected band size for ANGPTL3 is at 54KD.[/list_product_images]
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